ScienceDaily

A decades-old compound may point to a new way of treating obesity by making the body burn more energy rather than simply reducing appetite. In mice, TOFA increased energy use by as much as 18%, reduced body fat without significant muscle loss, and improved blood sugar, triglycerides, and fatty liver disease. It also produced stronger results when combined with GLP-1 drugs such as Ozempic, Wegovy,…

Researchers have used AI to uncover the DNA signature of a key genetic “switch” involved in turning genes on. After analyzing about 500,000 DNA sequences, the model identified the initiator in roughly 60% of human genes. The breakthrough could help predict the effects of harmful mutations and eventually contribute to decoding the broader genetic instructions that control gene activity throughout …

Scientists have developed an ultrathin coating that could dramatically improve how efficiently heat is transferred during condensation. By turning tiny polymer structures once considered “defects” into places where water droplets can form, then helping those droplets detach quickly, the new surface keeps exposing fresh areas for condensation. In tests on copper tubes, it transferred heat up to 5.…

Researchers have found a way to slash the processing time for 3D-printed zirconia crowns from as much as 100 hours to under 30 minutes. The advance could eventually let dentists print strong, customized permanent crowns for patients within a single appointment.

A massive analysis involving more than 100 million people has found strong links between recreational drug use and stroke, including among younger adults. Cocaine was associated with nearly double the risk of stroke, amphetamines with more than double the risk, and cannabis with a 37% increase.

An abandoned farm field became a flourishing wildflower meadow within little more than a decade, with plant diversity doubling and thousands of orchids appearing naturally. The discovery suggests that simply giving nature time to recover could be a powerful and inexpensive tool for restoring biodiversity.

Researchers at CERN have created microscopic versions of the early Universe by colliding surprisingly small atomic nuclei at nearly the speed of light. The collisions produced quark-gluon plasma, the ultra-hot matter believed to have filled the cosmos shortly after the Big Bang. Even more intriguingly, the particles left behind reveal the shape of the nuclei that created them, offering a new way …

Older adults with mild cognitive impairment and sleep problems who took at least 5,000 IU of vitamin D daily scored more than 13% higher on a cognitive test than those taking none. The preliminary findings suggest vitamin D could be worth studying as a potentially modifiable factor during an early window of cognitive decline.

Researchers have uncovered a possible reason why the Alzheimer’s risk gene APOE4 can disrupt the brain long before memory problems begin. In mice, APOE4 increased a protein called Nell2, shrinking neurons and making memory circuits unusually active. That early hyperactivity predicted worse memory later in life. Reducing Nell2 in adult mice reversed the abnormal changes, raising hopes for a new wa…

Mice that developed compulsive drinking after alcohol abstinence showed more than double the activity in a brain region associated with stress and addiction. Because the signal appeared before they drank again, researchers think it could eventually help predict who is most at risk of relapse.

Astronomers have found stars that repeatedly skim past supermassive black holes, surviving each encounter while producing a new burst of light. In some systems, those flares mysteriously fade with every return. Researchers now think the key may be stars that were already spinning extremely fast before being captured. That rapid rotation could explain both the fading flares and how the stars ended…

Greenland sharks may live for 400 years without suffering the kind of retinal decline normally associated with aging. Researchers found healthy eye tissue and active proteins specially adapted for seeing blue light in the dim Arctic depths. DNA repair mechanisms may help keep their eyes functioning across centuries. The discovery could eventually offer new clues for protecting human vision as we …

Astronomers using JWST have discovered that massive early galaxies contain far more small, faint stars than expected. That hidden population could make some of these galaxies three to four times more massive than previous estimates. The finding makes it even harder to explain how enormous, mature galaxies formed so soon after the Big Bang. It could also suggest that planets around low-mass stars …

Exercise may not be a powerful weight-loss tool on its own, but it appears to play a much bigger role in preventing lost weight from returning. By preserving muscle, supporting metabolism, improving fat burning, and regulating appetite and blood sugar, regular activity can make long-term weight maintenance easier.

Peppermint oil may have an unexpected benefit for people with mildly high blood pressure. Adults who took a small dose twice daily for 20 days saw their systolic blood pressure fall by an average of 8.5 mmHg, while a placebo group showed little change. Researchers say the inexpensive oil could eventually provide a simple additional option for managing elevated blood pressure.