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Mexico's "most powerful and ruthless" cartels operate in all 50 states and clash in American cities, the U.S. Drug Enforcement Administration said in a May report.

The Jalisco and Sinaloa cartels have flooded major U.S. cities with meth and fentanyl and use violence to protect their turf, the report found. 

"The deadly reach of the Mexican Sinaloa and Jalisco cartels into U.S. communities is extended by the wholesale-level traffickers and street dealers bringing the cartels’ drugs to market, sometimes creating their own deadly drug mixtures," the DEA report says. "Together, the Sinaloa and Jalisco cartels have caused the worst drug crisis in U.S. history."

The DEA's National Drug Threat Assessment report details the cartels' leadership structures, the areas they control, how they operate and their global reach beyond Mexico and the U.S. 

KILLERS IN MEXICO ‘CAN LOOK LIKE ANYONE,’ INCLUDING A KIM KARDASHIAN LOOKALIKE OR SEVEN-YEAR-OLD CHILD

CJNG Drug Cartel

The initials of the drug cartel "Jalisco Nueva Generacion" (CJNG) are seen in graffiti on a wall in Lagos de Moreno, Jalisco State, Mexico, on August 29, 2023. Bloody handprints on a wall offer a clue to the barbarity that unfolded in a house where five young Mexican men were tortured and presumably murdered by drug cartel hitmen.  (Ulises Ruiz/AFP via Getty Images)

Synthetic drugs like fentanyl are more potent than plant-based drugs, cheaper to make and easier to move, which allows both cartels to infiltrate American and control all aspects of the drug trade from production to delivery. 

SURFERS' DEATHS IN MEXICO ‘EERILY’ SIMILAR TO SAN DIEGO COUPLE'S MURDERS FOR BEDDING: ‘ANYONE CAN BE KILLED FOR ANYTHING’

Sinaloa and Jalisco have "effectively eliminated any competition in U.S. markets" and "dictate the flow of nearly all illicit drugs" into the country, according to the report, which notes that thousands of cartel-linked dealers currently operate in the U.S. 

Late last week, the "Skittles Man," whose real name is Roque Bustamante, was one of seven Sinaloa Cartel members arrested in Florida for allegedly supplying thousands of Mexican-made fentanyl pills, according to federal prosecutors. 

The notorious nickname was created because he allegedly sold large supplies of rainbow-colored fentanyl pills. 

Map showing Mexico's "most powerful and ruthless" cartel operates in all 50 states.

Mexico's "most powerful and ruthless" cartel operates in all 50 states, the DEA says.  (DEA's 2024 National Drug Threat Assessment)

Rainbow colored fentanyl seizures

Cartels sell rainbow fentanyl pills, the DEA says. (Drug Enforcement Administration)

An undercover law enforcement operation also busted the cartel members arranging a weapons-smuggling operation into Mexico, including .50 caliber high-powered rifles, court documents allege. 

During the investigation, the DEA seized about 21 kilograms of pure fentanyl, 70,000 rainbow-colored fentanyl pills, 3,000 M30 blue fentanyl pills, 243 pounds of crystal meth, two kilos of cocaine and 24 guns, including 18 rifles and six pistols.

ONCE ‘OFF LIMITS,’ MEXICAN CARTELS WAR OVER POPULAR RESORTS LIKE CANCUN: ‘THE RULES HAVE CHANGED’

In late April, 12 traffickers tied to the Jalisco cartel were sentenced to 4.5 to 40 years in federal prison after they were busted in Del Rio, Texas, in 2021 for coordinating a shipment of nearly 200 kilograms of liquid methamphetamine worth $9.9 million.

Over the course of that particular investigation, law enforcement seized about 650 kilograms of methamphetamine, 17 guns, $220,922 in cash and $12,200 in real and personal property, federal North Texas prosecutors said. 

Ovidio Guzman gunfight

A truck burns on a street in Culiacan, Sinaloa state, Thursday, January 5, 2023. Mexican security forces captured Ovidio Guzmán, an alleged drug trafficker wanted by the United States and one of the sons of former Sinaloa Cartel boss Joaquín "El Chapo" Guzmán, in a pre-dawn operation Thursday that set off gunfights and roadblocks across the western state’s capital.  (AP Photo/Martin Urista)

ADVANCE FOR USE SUNDAY, JUNE 5, 2011 AND THEREAFTER - In this Wednesday, April 6, 2011 picture, a state police officer belonging to a newly-formed elite group participates in a patrol during a preventive surprise search at a low-income neighborhood in the Pacific resort city of Mazatlan, Mexico. The so-called Elite Group has been deployed to hotspots around Sinaloa state, dismantling neighborhood gangs in the port city of Mazatlan and making significant arrests, according to local officials. Sinaloa, which shares a name with Mexico's most powerful drug cartel, is known as the cradle of drug trafficking in the country. (AP Photo/Dario Lopez-Mills)

In this Wednesday, April 6, 2011, picture, a state police officer belonging to a newly formed squad participates in a patrol during a preventive surprise search in a low-income neighborhood in the Pacific resort city of Mazatlan, Mexico. The so-called Elite Group has been deployed to hotspots around Sinaloa state, dismantling neighborhood gangs in the port city of Mazatlan and making significant arrests, according to local officials. Sinaloa, which shares a name with Mexico's most powerful drug cartel, is known as the cradle of drug trafficking in the country. (AP Photo/Dario Lopez-Mills)

There were nearly 38,000 fentanyl-related deaths in the first six months of 2023, according to the DEA report. 

"Fentantyl is the deadliest threat the U.S. has ever faced," the report says. "Fentanyl and other synthetic drugs, like methamphetamine, are responsible for nearly all the fatal drug overdoses and poisonings in our country."

READ THE DEA REPORT – APP USERS, CLICK HERE:

Operations Last Mile and Overdrive: Drugs, money and violence

The DEA’s "Operation Last Mile" tracked the Jalisco and Sinaloa cartels' distribution networks across the country. 

In total, the major operation, which included countless law enforcement agencies from the local to federal levels, included 1,436 investigations and resulted in 3,337 arrests. 

MEXICAN CARTELS USE U.S. BORDER TO ARM THEMSELVES WITH ‘MILITARY-GRADE’ WEAPONS: DOCS

The DEA seized nearly 44 million fentanyl pills, over 6,500 pounds of fentanyl powder, more than 91,000 pounds of methamphetamine, 8,497 firearms and over $100 million, according to the report. 

In 2023, law enforcement agencies within 150 miles of the border conducted nearly 600 bulk cash seizures valued at $18 million, the report says. 

Most of the bulk cash seizures in 2023 were executed in Arizona, California, Texas and New Mexico. 

Cartel Mexico California

DEA agents search a residential house during the arrest of a suspected drug trafficker on Wednesday, March 11, 2020, in Diamond Bar, California. (AP Photo/Richard Vogel)

Moving forward, the DEA has Sinaloa and Jalisco cartel members in its scope with "Operation Overdrive." 

"DEA’s top operational priority is to relentlessly pursue and defeat the two Mexican drug cartels … that are primarily responsible for driving the current fentanyl poisoning epidemic in the United States," the report says. 

The operation "puts resources into the U.S.’s most violence- and overdose-plagued cities to target the violent dealers who kill thousands of Americans every week with fentanyl and with weapons."

Graphic of operation last mile stats for the New Orleans DEA field office

Operation Last Mile was a year-long DEA investigation from May 2022 to May 2023.  (Fox News)

Jalisco Cartel members admitted to coordinating the shipment of a load of 199.97 kilograms of liquid methamphetamine – with a street value of up to $9.9 million – from Mexico to Dallas, Texas federal prosecutors said.

Jalisco Cartel members admitted to coordinating the shipment of a load of 199.97 kilograms of liquid methamphetamine – with a street value of up to $9.9 million – from Mexico to Dallas, Texas federal prosecutors said.   (US Attorney's Office North District of Texas)

Mexico's president has pushed back on outside pressure to deal with the cartels

Mexican President Andrés Manuel López Obrador and his administration have routinely denied or downplayed cartel violence and criminal activity. 

He omitted any reference to drugs, crime or the cartels during his September 2023 State of the Union address. 

MEXICAN PRESIDENT CALLS GANGS, CARTELS ‘RESPECTFUL PEOPLE’ WHO 'RESPECT THE CITIZENRY

He also said last March that his government was "not going to permit any foreign government to intervene in our territory, much less that a government’s armed forces intervene," Al Jazeera reported.

Mexico had a chance to rip a major hole in the Jalisco cartel after arresting the brother of the cartel's kingpin, Nemesio "El Mencho" Oseguera Cervantes.

Nemesio Oseguera

Nemesio Oseguera, aka "El Mencho," the leader of the Jalisco cartel. (U.S. Treasury Dept)

WATCH: MEXICAN PRESIDENT DENIES CARTELS SUPPLYING AMERICA WITH DRUGS

El Mencho's brother, Abraham Oseguera, was captured on April 21 by the Mexican army, but he was a free man nine days later. Mexican Judge Rogelio Leon released Oseguera, claiming there were no legal grounds to charge or keep him. 

‘EL CHAPO’ DENIED REQUEST FOR PHONE CALLS AND VISITS, CALLING IT ‘UNPRECEDENTED DISCRIMINATION’

Jay Armes III, a private investigator who specializes in kidnappings in Mexico, told Fox News Digital that he expected a "shock-and-awe" violence campaign similar to when the son of former Sinaloa cartel boss Joaquín "El Chapo" Guzmán, Ovidio Guzman Lopez, was arrested in 2019. 

"When (El Chapo's son) was captured by police, his soliders, his henchmen basically put the entire town of Culiacan under siege," Armes said. "They blocked all six entrances and exists to the city. They captured buses and lit them on fire."

Ovidio Guzman

El Chapo's son. (AP Images)

WATCH: SHOOTOUT BETWEEN CARTELS AND MEXICAN AUTHORITIES

The cartel also opened fire on Mexican police and military, shot down a Blackhawk helicopter and passenger aircraft and blasted airports so authorities couldn't get Lopez out of the country, he said.

"They were wreaking mayhem throughout the city to the point where it became so painful that the president of Mexico himself instructed law enforcement to release him," Armes said. "He said it wasn't worth the lives of so many people for the life of one."

AMERICAN KIDNAPPED IN MEXICO, LEFT TO DIE IN JUNGLE WITH EYES, WRISTS TAPED

In total, 30 people died before he was released. 

But none of that happened with El Mencho's brother, proving how terrifying the threat of the Jalisco cartel really is. 

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"The most dangerous enemy is not always the one that can exert the most brute force," Armes said. "The most dangerous enemy is actually the one who can accomplish their objective, or get themself out of a giant problem, without firing a single shot.

"And that's what you see here (after El Mencho's brother was released). I'll let you draw your own conclusions."