THE MEDICAL NEWS

The most comprehensive review to date has identified the most effective bipolar disorder treatments across different age groups and mood phases. It was published today in The BMJ.

Researchers have identified seven proteins in the blood that could enable better blood tests for Alzheimer's disease.

The brain's immune cells are increasingly recognized as key players in Alzheimer's disease, but exactly how they change as the disease develops has remained unclear.

Light therapy may improve alertness and attention/reaction time during simulated night shifts, with the strongest benefits appearing after light exposure. Effects on executive function were smaller and largely limited to treatment, while substantial study heterogeneity and limited real-world evidence warrant caution.

A Western dietary pattern was associated with faster attention decline among older adults carrying the APOE ε4 allele, while no significant cognitive associations emerged for a Prudent dietary pattern. However, the Western diet association lost statistical significance after excluding participants with possible baseline cognitive impairment, making the finding exploratory.

. Early-life stress increased SETD7 and H3K4me1 in the ventral tegmental area of mice, creating an epigenetically primed state that heightened later transcriptional, neuronal, and behavioral responses to stress. Reducing Setd7 during development lowered H3K4me1 and weakened these stress-sensitizing effects, identifying a mechanism that may help explain how early adversity leaves lasting biologica…

Broken String Biosciences, a biotechnology company enabling gene editing teams to accelerate development of safer, more effective genetic medicines, today announced the launch of BaseMap™ ABE. Built on the Company\'s INDUCE-seq® technology, BaseMap ABE extends the platform\'s capabilities to support adenine base editing (ABE) applications.

E-scooter riders admitted with moderate-to-severe trauma showed a distinct injury profile, with proportionally more traumatic brain, vascular, and internal organ injuries than motorcyclists and fewer fractures. Rental-scooter data also linked greater reported injury severity with younger age and female sex, while collision rates varied with area-level deprivation.