THE MEDICAL NEWS

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

Mpox virus clade Ib shows a longer and more variable incubation period than previously characterized clades, with symptom onset extending well beyond 21 days in a substantial minority of cases. Incubation varies by transmission route, with shorter intervals after sexual exposure and longer periods following nonsexual community transmission, raising implications for surveillance and postexposure g…

A large volcanic eruption or cluster of eruptions in the mid-1340s triggered severe climate anomalies that drove harvest failures across parts of Europe. These shocks reshaped Mediterranean grain trade routes, likely introducing plague-infected fleas into Italian ports and helping ignite the Black Death.

Nancy Hunt arrived at an emergency room from a Genesis HealthCare nursing home in Pennsylvania in such dreadful shape, including maggots infesting her gangrened foot, that the hospital called an elder abuse hotline and then the police, her son alleged in a lawsuit.

With cannabis-related vehicle crashes on the rise, a new study suggests that prevention campaigns shouldn't focus just on young people.

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia.

The negative health impacts from contamination by so called "forever chemicals" in drinking water costs the contiguous U.S. at least $8 billion a year in social costs, a University of Arizona-led study has found.

More than half of patients in a Phase III clinical trial who received a limited course of the experimental monoclonal antibody ianalumab for primary immune thrombocytopenia (ITP), an autoimmune disorder that can cause life-threatening bleeding, were able to maintain safe platelet counts without serious bleeding episodes for at least one year.