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Athletes struggle to recognize subtle signs of coach sexual abuse14:38 A study carried out by GIKAFIT group of the EHU-University of the Basque Country shows that more than 80% of the athletes identify the more explicit behaviors but not other, more normalized, forms of interaction. Structural insights into synchronous calcium channel gating in muscle cells14:06 Using cryo-electron microscopy, researchers at the Max Delbrück Center have revealed how muscle cell calcium channels open synchronously. Less is more: Exercise rivals common pain meds14:06 From osteoarthritis to a splitting migraine, when you’re experiencing pain, exercise can seem like the last thing you want or think you should do. But according to new Adelaide University research it could be one of the most effective ways to help ease your symptoms. GLP-1s linked to nutritional deficiencies in children9:46 Children prescribed GLP-1 medications for weight loss, prediabetes, or type 2 diabetes are at risk for nutritional deficiencies – diagnosed in nearly one in six patients (16.8%) within the first year – according to a new study published in the journal Childhood Obesity. From lab to living room: Revolutionary Utah bionic arm enters first home trial9:46 At age 16, Alexander “Avi” Davidson fell 35 feet from the top of a telephone pole, an accident that left him paralyzed from the waist down and led to the amputation of his left arm below the elbow. As GLP-1 drugs become more complex, their effects on the heart are getting harder to predict8:11 A brief report reviews emerging GLP-1 receptor co-agonists that also target GIPR, GCGR, and other receptors, examining their metabolic benefits alongside known and predicted cardiac effects. The authors highlight substantial species differences, warning that mouse heart studies may fail to predict responses in human cardiac tissue and that many proposed cardiac effects still require direct testin… GLP-1 drugs may influence chronic pain through gut-brain and immune pathways7:39 Researchers reviewed evidence linking GLP-1 and GLP-1 receptor agonists to chronic pain modulation through gut microbial, neuroimmune, vagal, and metabolic pathways, with the strongest clinical evidence currently involving knee osteoarthritis and idiopathic intracranial hypertension headache. Much of the proposed biology remains supported by preclinical research, and human studies have yet to est… Advances in chemistry and delivery are taking oligonucleotide medicines beyond rare diseases7:07 A review in Cell Reports Medicine examines how advances in oligonucleotide chemistry and delivery have established ASOs and RNA interference therapies as a class of genetic medicines, with 21 oligonucleotides approved at the time of writing. It also identifies extrahepatic delivery, safety, target validation, individualized treatment, and data quality as priorities as the field expands into commo… First foods bring an early functional shift in the infant gut microbiome6:35 Researchers analyzing paired gut microbiome samples from 125 Irish infants found that complementary feeding was associated with early changes in microbial composition and metabolic potential, including an increased capacity for complex carbohydrate metabolism. Breastfeeding duration was more closely associated with microbial community development than the timing of solid-food introduction, while … |
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