THE MEDICAL NEWS |
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Researchers uncover genetic cause of spontaneous spinal CSF leaks3:38 Researchers at Cedars-Sinai Health Sciences University and Johns Hopkins University have identified genetic mutations that may explain why some people develop a spontaneous cerebrospinal fluid (CSF) leak in the spine. First human trial targets aging immune cells for healthier immunity3:38 A first-in-human clinical trial of an immune rejuvenation therapy designed to restore the function of worn-out T cells is expected to begin later this year, building on research led by UCL scientists into the mechanisms of immune aging. WashU study identifies shared target for a new diarrhea vaccine20:21 The bacteria enterotoxigenic E. coli and Shigella together cause hundreds of millions of infections each year and are among the leading causes of diarrheal death, especially in children. Key Alzheimer's protein actively protects neurons from nuclear damage19:46 Researchers at Niigata University's Brain Research Institute have uncovered a new function of amyloid precursor protein (APP), a molecule long studied as the precursor to amyloid-β (Aβ) in Alzheimer's disease (AD). Robotics and augmented reality improve precision in complex jaw surgery19:46 RAMRS consists of two modules. The first, robot‑assisted osteotomy, uses an optical tracking system and a collaborative robotic arm to guide the bone saw. A hand‑eye calibration procedure determines the exact pose of the robot's end‑effector relative to a tracking marker. Autism study reveals shared brain cell changes during early development19:10 Hundreds of genes have been linked to autism, yet the precise molecular and cellular mechanisms behind it remain largely unclear. Weight-loss medications lessen the risk of violent criminal behavior19:10 Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for diabetes and obesity, but studies have found evidence that the medications may also influence behavior, such as supporting impulse control and reducing substance use and alcohol consumption by potentially interacting with the brain's reward and stress systems. Developing brain cells routinely repair severe DNA damage during migration19:10 Newborn nerve cells must squeeze through crowded, narrow spaces-through dense tissue, past other cells, between fibers-to reach the areas where they form neural circuits in the brain cortex. AI-designed drug for Parkinson's begins first human trial18:36 Insilico Medicine ("Insilico", HKEX: 3696), a clinical-stage biotechnology company powered by generative artificial intelligence (AI), today announced it has achieved the first clinical milestone in its co-development collaboration with Hygtia Therapeutics with the completion of first-in-human dosing in the Phase I study of ISM8969. Novel gene therapy appears to be safe for Friedreich ataxia cardiomyopathy18:36 A new gene therapy appears to be safe in patients diagnosed with Friedreich ataxia cardiomyopathy, a progressive and fatal inherited cardiac disease, according to a phase 1 clinical trial led by Weill Cornell Medicine researchers. |
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