THE MEDICAL NEWS

An eight-week randomized trial found that daily perilla oil increased plasma and red-cell ALA, plasma EPA, and platelet closure time in healthy smokers. Perilla oil also reduced TNF-α and TBX21 gene expression, but it did not improve broader coagulation, lipid, endothelial, or postprandial markers.

A phase 3 randomized trial of 830 young children with severe early childhood caries found that 38% silver diamine fluoride arrested 54.0% of eligible cavitated dentin lesions at six months, compared with 22.5% after placebo. The noninvasive treatment showed clinically meaningful efficacy, but about half of the lesions remained active, supporting close monitoring and additional preventive care.

A long-running debate over prescription drug costs has centered on whether drug manufacturers are better rewarded for truly innovative medicines or so-called "me-too" drugs that may offer only incremental improvements over existing treatments but still command high prices.

USC researchers have developed an approach that uses artificial intelligence to generate detailed maps that highlight differences in how distinct parts of the brain age.

A new review explores how advances in understanding X chromosome inactivation (XCI) are creating potential therapeutic opportunities for a range of X-linked genetic disorders, including Rett syndrome, Fabry disease, Duchenne muscular dystrophy, hemophilia, and others.

As the use of GLP-1 and other incretin-based medications for obesity continues to grow worldwide, researchers at Marshall University have contributed to an international effort to address one of medicine's most pressing unanswered questions: How should these medications be used by women before, during and after pregnancy?

UCLA researchers have identified a promising strategy to make a new class of targeted cancer therapies more effective against one of the deadliest forms of prostate cancer, potentially overcoming treatment resistance that has limited their success.

Every time a virus invades a person, it collides with thousands of years of human history. A study led by researchers at the USC Dornsife College of Letters, Arts and Sciences and Howard University suggests that some of the genes involved in the body's immune response today bear the marks of ancient battles with infectious diseases.