THE MEDICAL NEWS

A randomized, double-blind, placebo-controlled trial found that low-dose tizanidine did not provide sustained reductions in headache burden over 12 weeks in people with episodic migraine, despite a transient improvement with the 1 mg dose at week 4. Exploratory analyses suggested that smoking and sex may influence tizanidine exposure, while sex-specific efficacy signals remained hypothesis-genera…

Researchers applied six proteomic aging clocks to serum samples from a phase 2a trial of rentosertib in people with idiopathic pulmonary fibrosis and found treatment-associated shifts toward younger predicted biological-age profiles, particularly with the 30 mg twice-daily regimen. Additional proteomic analyses linked treatment to changes in senescence, metabolism, growth-factor signaling, and fi…

Bruker Corporation today announced a strategic collaboration with Translucence Biosystems, Inc., a leading provider of tissue‑clearing solutions, to expand its workflow for cleared tissue imaging.

Yourgene Health (part of the Novacyt Group), an international molecular diagnostics company with a broad portfolio of integrated technologies and services, announces the commercial launch of its In Vitro Diagnostic Regulation (IVDR)-certified Yourgene® Insight DPYD assay, expanding the Company's clinical genetics portfolio across regulated European markets.

Gut microbiota composition explained more variation than chronological age in nearly all inflammatory cytokines and most physiological measures examined, with specific microbial profiles linked to markedly different patterns of inflammation across adulthood. People with the Bacteroides 2 enterotype showed an inflammaging-like profile decades earlier than other groups and had a higher risk of subs…

Nearly half of health boards in England are deliberately delaying care for patients by imposing minimum waiting times in an attempt to manage demand and control costs, reveals exclusive data published by The BMJ today.

In female rats with repetitive mild head injury, psilocybin reduced acute imaging measures consistent with vasogenic edema and phosphorylated tau while altering vascular reactivity, functional connectivity, neurotrophic proteins, and lipid signaling. The findings provide preclinical evidence of potential therapeutic effects, but behavioral benefits were limited, and whether these biological chang…

A new study led by investigators from Mass General Brigham reveals that certain features in the spleen hidden within imaging scans may signal a person's risk of coronary artery disease (CAD), suggesting targets for prevention and treatment.