ScienceDaily

Deep-brain recordings showed that Mounjaro and Zepbound briefly shut down the craving circuits linked to food noise in a patient with severe obesity. Her obsessive thoughts about food disappeared as the medication quieted the nucleus accumbens, the brain’s reward hub.

Using less ipilimumab appears to make melanoma immunotherapy both safer and more effective, with dramatically better response and survival outcomes. The findings suggest that reducing side effects may be the key to maximizing the benefits of these powerful treatments.

Researchers revealed that the microbial metabolite TMA can directly block the immune protein IRAK4, reducing inflammation and improving insulin sensitivity. The molecule counteracts damage caused by high-fat diets and even protects mice from sepsis. Since IRAK4 is a known drug target, this pathway could inspire new diabetes therapies. The study highlights how gut microbes and nutrition can work t…

Researchers have built a fully implantable device that sends light-based messages directly to the brain. Mice learned to interpret these artificial patterns as meaningful signals, even without touch, sight, or sound. The system uses up to 64 micro-LEDs to create complex neural patterns that resemble natural sensory activity. It could pave the way for next-generation prosthetics and new therapies.

High-resolution imaging has revealed the internal layout of chromatin condensates, showing how DNA fibers fold and interact within these droplet-like structures. The findings connect molecular architecture to the broader behaviors of these droplets in cells.

A large Mayo Clinic study shows that current guidelines fail to detect nearly 90% of people with familial hypercholesterolemia, a common inherited cause of dangerously high cholesterol. Many affected individuals already had early heart disease but never met testing criteria. Routine DNA screening could dramatically expand detection and prevention. The research underscores the need for genomics-dr…

Scientists found that kale’s prized nutrients are hard for the body to absorb unless they’re eaten with oil. Cooking doesn’t improve absorption, but adding oil-based dressings—or even more advanced nanoemulsion sauces—does. These combinations dramatically increase access to kale’s carotenoids. The research could inspire new, healthier dressings designed to supercharge everyday vegetables.

A newly analyzed set of climate data points to a major volcanic eruption that may have played a key role in the Black Death’s arrival. Cooling and crop failures across Europe pushed Italian states to bring in grain from the Black Sea. Those shipments may have carried plague-infected fleas. The study ties together tree rings, ice cores, and historical writings to reframe how the pandemic began.

XRISM’s high-precision X-ray data revealed unusually strong signatures of chlorine and potassium inside the Cassiopeia A supernova remnant. These levels are far higher than theoretical models predicted, showing that supernovae can be major sources of these life-critical elements. Researchers believe powerful mixing deep inside massive stars is responsible for the unexpected boost. The findings re…

Garlic extract is emerging as a surprisingly powerful contender to chlorhexidine, the long-standing “gold standard” in antimicrobial mouthwashes. A systematic review of clinical studies shows that higher-concentration garlic mouthwash can rival chlorhexidine in killing bacteria—sometimes outperforming it—while offering a more natural alternative.

Human biology evolved for a world of movement, nature, and short bursts of stress—not the constant pressure of modern life. Industrial environments overstimulate our stress systems and erode both health and reproduction. Evidence ranging from global fertility declines to chronic inflammatory diseases shows the toll of this mismatch. Researchers say cultural and environmental redesign, especially …

Researchers have developed a new oral drug that boosts metabolic activity in muscle rather than altering appetite like GLP-1 drugs. Early trials suggest it improves blood sugar control and fat metabolism while preserving muscle mass, with fewer side effects. Because it acts through a different mechanism, it could be paired with GLP-1 treatments for even stronger results.

A century-old North Atlantic cold patch is now linked to a long-term slowdown in the AMOC, the climate-regulating conveyor belt of ocean water. Only weakened-AMOC models match observed temperature and salinity patterns, overturning recent model trends. This slowdown affects weather systems, jet streams, and marine life throughout the Northern Hemisphere. The discovery sharpens climate forecasts a…

A new radiocarbon study has clarified the timing of the colossal Thera eruption, placing it before Egypt’s New Kingdom. Researchers analyzed artifacts tied to Pharaoh Ahmose, gaining rare access to museum materials. Their results favor a younger chronology for early 18th Dynasty Egypt. The revised timeline reshapes regional historical connections.

Researchers have found scientific support for the viral claim that rosemary can improve wound healing. Carnosic acid, a natural antioxidant in rosemary, promoted scar-free healing in mice by activating a nerve sensor tied to regenerative repair. Rosemary proved more potent and gentler than other herbs or compounds that target the same pathway. The work hints at a low-cost future option for reduci…